TP53 DRIVES ABSCOPAL EFFECT BY SECRETION OF SENESCENCE-ASSOCIATED MOLECULAR SIGNALS IN NON-SMALL CELL LUNG CANCER

TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer

Abstract Background Recent developments in abscopal effect strongly support the use of radiotherapy for the treatment of metastatic disease.However, deeper understanding of the molecular mechanisms underlying the abscopal effect are required to best benefit a larger proportion of patients with metastasis.Several groups including ours, reported the

read more




Contrasting Inflammatory Signatures in Peripheral Blood and Bronchoalveolar Cells Reveal Compartment-Specific Effects of HIV Infection

The mechanisms by which HIV increases susceptibility to tuberculosis and other respiratory infections are incompletely understood.We used transcriptomics of paired whole bronchoalveolar lavage cells (BLCs) and peripheral blood mononuclear cells to Bath salts compare the effect of HIV at the lung mucosal surface and in peripheral blood.The majority

read more